Your Complete Guide to Macrodosing


The use of psychedelics for therapeutic and recreational purposes has a history stretching back thousands of years, from indigenous communities using hallucinogenic plants in their rituals to the recent surge in psychedelic therapy research. Macrodosing is the term used to describe the practice of consuming full, or “trip-inducing,” doses of psychedelics. This comprehensive guide explores macrodosing, its potential benefits, risks, and how to practice it safely.

Learn more about Psychedelics such as LSD through out in-depth post: Your Complete Guide to LSD

Understanding Macrodosing

What is Macrodosing?

Macrodosing refers to the practice of consuming a full dose of a psychedelic substance, an amount sufficient to produce profound changes in perception, mood, and cognitive processes. Unlike microdosing, which involves taking sub-perceptual doses of these substances, macrodosing often leads to a full psychedelic experience, also known as a “trip.”

History of Macrodosing

The use of psychedelics in higher doses is not a new phenomenon. Many indigenous cultures have been using psychoactive substances like peyote, ayahuasca, and psilocybin mushrooms in their rituals and healing practices for millennia. In the modern context, macrodosing became prominent during the countercultural movement of the 1960s and is gaining renewed interest due to emerging research on the therapeutic potential of psychedelics.

Commonly Macrodosed Substances

LSD and Psilocybin

The two most commonly macrodosed substances are lysergic acid diethylamide (LSD) and psilocybin. Both these substances can induce profound changes in perception, thought processes, and mood at higher doses.

Other Substances

Other substances that are often used for macrodosing include mescaline, derived from certain cacti, DMT, found in ayahuasca, and synthetic substances such as MDMA. The effects of these substances vary widely, and individuals should do extensive research and seek professional advice before deciding to macrodose with these substances.

Potential Benefits and Risks of Macrodosing

Possible Benefits

Research has shown that macrodosing psychedelics can have numerous potential benefits. These include inducing mystical or spiritual experiences, promoting psychological insight, and providing relief from conditions like depression, anxiety, and post-traumatic stress disorder (PTSD).

Possible Risks

The risks associated with macrodosing can be significantly higher than those of microdosing. These include the possibility of having a “bad trip,” which can result in intense fear, anxiety, and paranoia. Physically, macrodosing can lead to nausea, increased heart rate, and in rare cases, psychosis in individuals predisposed to such conditions. It’s also important to note the potential legal repercussions, as many of these substances remain illegal in many jurisdictions.

Macrodosing Safely and Responsibly

Preparation and Dosage

The dosage will depend on the specific substance being used. However, it’s crucial to start with a lower dose and slowly increase it over time. This reduces the likelihood of experiencing adverse effects.

Set and Setting

The environment and the mental state of the individual (set and setting) play a crucial role in determining the quality of the psychedelic experience. It’s important to ensure that the macrodosing session takes place in a safe, comfortable, and controlled environment.

Guidance and Support

Professional guidance is crucial when macrodosing, especially for those who are new to it. This might include having a trusted “trip sitter” present or seeking the help of a professional psychedelic guide. Some countries, such as the Netherlands, even have legal psychedelic retreats where substances can be taken under professional supervision.


Macrodosing can be a deeply transformative practice, offering potential benefits for mental health and personal development. However, it is not without risks. Ensuring safety, understanding the legal implications, and having appropriate guidance are crucial factors to consider. As scientific research into the therapeutic use of psychedelics progresses, our understanding of how to best use these substances for healing and growth will undoubtedly continue to evolve. Whether you’re considering macrodosing for personal development, therapeutic benefits, or spiritual exploration, this guide serves as a starting point for your informed and conscious journey into the world of psychedelics.

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