Your Complete Guide to Microdosing


Microdosing, a trending topic in contemporary psychopharmacology, refers to the practice of consuming small amounts of psychoactive substances, primarily psychedelics like LSD or psilocybin. The quantities ingested are often too low to cause noticeable mind-altering effects, but they are believed to elicit positive impacts on creativity, mood, and cognitive function. This comprehensive guide explores the realm of microdosing, its potential benefits, risks, and guidelines for safe practices.

Learn about Macrodosing through our in-depth post: Your Complete Guide to Macrodosing

Understanding Microdosing

What is Microdosing?

Microdosing is the routine ingestion of fractional doses of psychedelic substances. While a typical recreational dose of LSD ranges between 100 to 200 micrograms, a microdose might be anywhere from 5 to 20 micrograms. This sub-perceptual dosage is supposed to influence the consumer’s perception and cognition subtly without provoking a full-blown psychedelic experience or “trip.”

History of Microdosing

While microdosing has gained popularity in recent years, especially among professionals in high-stress careers, the practice is not entirely new. Indigenous communities have long used psychoactive plants in low doses for various purposes. Albert Hofmann, the Swiss chemist who first synthesized LSD, was a known proponent of microdosing, asserting that it could have positive psychological effects.

Microdosing Substances

LSD and Psilocybin

The most commonly microdosed substances are lysergic acid diethylamide (LSD) and psilocybin, the active compound in “magic mushrooms.” Both substances are known for their potent psychedelic effects at regular doses, but at microdoses, they are believed to enhance mood, creativity, and focus.

Other Substances

While less common, other substances like mescaline (found in peyote and San Pedro cacti), DMT (found in ayahuasca), and synthetic substances like MDMA have also been used for microdosing. Each substance has its unique characteristics and effects, and individuals should research extensively before choosing to microdose with these substances.

Potential Benefits and Risks of Microdosing

Possible Benefits

Microdosers often report enhanced creativity, better emotional awareness, improved mental health, and increased energy levels. Some evidence suggests that microdosing can help reduce symptoms of anxiety, depression, and PTSD. However, it’s important to note that these benefits are largely anecdotal at present, with scientific research still in the early stages.

Possible Risks

Microdosing is not without its risks. These include potential legal repercussions, as many psychedelics remain illegal in many jurisdictions. On the physical and psychological front, possible risks include increased heart rate, nausea, and the onset or exacerbation of psychotic symptoms in predisposed individuals. Long-term effects are still unknown due to the lack of extensive scientific studies.

Microdosing Safely and Responsibly

Dosage and Schedule

A microdose typically ranges from 1/10th to 1/20th of a recreational dose. A commonly recommended schedule is one day on, two days off. This allows the body to avoid building up a tolerance.

Set and Setting

Just like with full-dose experiences, set (your mindset) and setting (your environment) can play crucial roles in your microdosing experience. Ensure you are in a positive mental state and comfortable, safe environment before you start.

Medical Guidance

It’s always advisable to seek medical advice before starting a new regimen like microdosing, especially for those with existing mental or physical health conditions or those taking other medications.


Microdosing is an emerging field that holds considerable potential, promising enhanced creativity, productivity, and mental wellbeing. As interest in this practice continues to grow, it’s essential to approach it responsibly, understanding the potential risks and benefits, and remembering that scientific research is still catching up with anecdotal reports. Whether you’re considering microdosing as a means of personal development, as a potential therapeutic tool, or simply out of curiosity, being well-informed will help ensure a safe and beneficial journey.

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